化学
区域选择性
组合化学
钠
转化(遗传学)
有机化学
催化作用
生物化学
基因
作者
Dong Li,Xiaoqing Wang,Yudi Nie,Shuo Yu,Haotong Li,Qian Zhao,Zeyu Fan,Yuqian Wang,Xiaoting Tan,Zhengsen Yu
标识
DOI:10.1002/ejoc.202200842
摘要
Abstract A simple and metal‐free perfluoroalkylation of 4‐quinolones have been developed using sodium perfluoroalkyl sulfinates and ammonium peroxodisulfate in DMSO under mild conditions. This transformation provides direct access to C‐3 perfluoroalkylated 4‐quinolones with broad functionality in satisfactory yields. The control experimental results suggest a radical mechanistic pathway was involved in this protocol.
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