Handbook of CH-Functionalization

Asymmetric intermediateScheme 1 Different types of desymmetrizations based on metal-promoted C--H activations.4 Transition Metal-Catalyzed Desymmetrizations Based on C--H Activation Processes CO 2 H R Pd(OAc) 2 (5 mol%) Boc-Ile-OH (10 mol%) BQ (5 mol%) KHCO 3 (0.5 equiv) tAmylOH, 90 °C CO 2 H R Ar 19 examples 35-73% yield, ee up to 97% Ar + S O Pd(OAc) 2 (10 mol%) Ac-Leu-OH (30 mol%) Ag 2 CO 3 (2 equiv) HFIP, 75 °C S O R 26 examples 31-72% yield, ee up to 99% R + (a) (c) P N H Pd(OAc) 2 (10 mol%) Boc-Tyr(tBu)-OH (20 mol%) BQ, Li 2 CO 3 (0.5 equiv) Ag 2 CO 3 (1.5 equiv) DMF/H 2 O, 40 °C + O Ar 1 F F CN