光热治疗
癌症研究
免疫系统
肿瘤微环境
免疫检查点
化学
癌症免疫疗法
体内
结直肠癌
免疫疗法
癌症
纳米技术
材料科学
医学
肿瘤细胞
免疫学
生物
内科学
生物技术
作者
Caiying Li,Tan Li,Kexin Niu,Zecong Xiao,Jing Huang,Ximin Pan,Yi Sun,Yongchen Wang,Decai Ma,Peiyi Xie,Xintao Shuai,Xiaochun Meng
出处
期刊:Biomaterials Science
[The Royal Society of Chemistry]
日期:2022-01-01
卷期号:10 (13): 3647-3656
被引量:6
摘要
One of the main challenges in applying the immune checkpoint blockade to treat colorectal cancer (CRC) is the immunosuppressive tumor microenvironment. Owing to its excellent cancer cell killing ability and immune activation, mild photothermal therapy (PTT) has shown bright promise to sensitize tumors to immune checkpoint inhibition through turning the immunologically "cold" tumors into "hot" ones. Herein, a mild photothermal effect-assisted theragnostic nanodrug (MnO2@MPDA-PEG NPs) is developed by incorporating MnO2 into PEGylated-mesoporous polydopamine nanoparticles (MPDA-PEG NPs). The presence of PEG endows the theragnostic nanodrug with high biostability. After accumulation in colorectal tumor, the theragnostic nanodrug responds to the tumor microenvironment, leading to the simultaneous release of Mn2+ which serves as a magnetic resonance imaging (MRI) contrast agent for tumor imaging. The released Mn2+ could also promote mild photothermal treatment-induced immune response, including the maturation of BMDC cells. In vivo antitumor studies on a CT26 model demonstrate that MnO2@MPDA-PEG NPs could be a promising dual-imaging theragnostic nanodrug to potentiate the systemic antitumor immunities.
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