18号染色体
遗传学
生物
女儿
染色体
小附加标记染色体
着丝粒
表型
22号染色体
进化生物学
基因
作者
Kenneth M. Taylor,Howard L. Wolfinger,Michael G. Brown,David L. Chadwick
标识
DOI:10.1111/j.1399-0004.1975.tb01515.x
摘要
A family is described in which the mother has an 18p‐ chromosome, one normal 18, and a probable i(18p). One of the daughters of this woman inherited the 18p‐ chromosome, and her phenotype resembles that of other 18p‐ cases. The other daughter inherited the presumed i(18p) chromosome, and her phenotype resembles that of some cases with extra, small metacentric chromosomes. The clinical, chromosomal, and familial evidence suggest that these abnormal chromosomes originated in the occurrence of one transverse break of the centromere and subsequent misdivision of a chromosome 18 in an earlier generation of this family. According to this interpretation, the mother is trisomic for 18p, one daughter is monosomic and the other daughter tetrasomic for this chromosomal region.
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