细胞毒性
含烷醇
酸浆
化学
立体化学
G2水电站
传统医学
生物化学
生物
植物
医学
体外
病理
替代医学
索马里风
作者
Yu Lan,Fang Rong Chang,Mei Jung Pan,Chin Chung Wu,Shu Jing Wu,Su Li Chen,Shyh Shyan Wang,Ming Wu,Yang Chang Wu
出处
期刊:Food Chemistry
[Elsevier]
日期:2009-09-01
卷期号:116 (2): 462-469
被引量:86
标识
DOI:10.1016/j.foodchem.2009.02.061
摘要
Investigation of the extracts of Physalis peruviana L. has led to the isolation of seven new withanolides, phyperunolide A (1), phyperunolide B (2), phyperunolide C (3), phyperunolide D (4), peruvianoxide (5), phyperunolide E (16), and phyperunolide F (17) together with ten known withanolides. The structure and absolute stereochemistry of all compounds were elucidated on the basis of CD and NMR spectral analysis, respectively. Compounds 1, 6, 7, and 9 showed cytotoxicity against lung cancer (A549), breast cancer (MDA-MB-231 and MCF7), and liver cancer (Hep G2 and Hep 3B) cancer cell lines. The presence of 5β,6β-epoxy-2-en-1-ones in withanolides is greatly helpful in cytotoxicity, it is a key known important factor to cytotoxicity; however, interestingly, the unusual 5-chloride withanolide, 9, displayed significant activity.
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