认知功能衰退
队列
内科学
队列研究
发病年龄
危险系数
比例危险模型
冲程(发动机)
临床痴呆评级
人口
作者
Albert Heyman,William E. Wilkinson,Barrie J. Hurwitz,Michael J. Helms,Carol Haynes,C. M. Utley,Lisa P. Gwyther
出处
期刊:Neurology
[Ovid Technologies (Wolters Kluwer)]
日期:1987-06-01
卷期号:37 (6): 980-980
被引量:205
摘要
Follow-up observations were made of 92 white patients with early-onset Alzheimer's disease to determine the demographic, clinical, and neuropsychological factors predictive of institutionalization or death. The cumulative mortality rate 5 years after entry into the study was 23.9%, compared with an expected rate of 9.5%. The 5-year cumulative rate of admission to nursing homes was 62.8%. The language ability of the patients on entry to the study, their scores on a brief screening test of cognitive function, and their overall ratings of clinical dementia were found to be predictors of subsequent institutional care and death. The age of the patients had a significant modifying effect on these predictive factors, resulting in a greater risk of institutionalization and death in younger patients with severe cognitive impairment as compared with older individuals with the same degree of dysfunction.
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