狭窄
医学
主动脉夹层
炎症
疾病
心脏病学
主动脉瘤
内科学
病理生理学
主动脉
血管疾病
内皮功能障碍
作者
Manolis Vavuranakis,Maria Kariori,Dimitrios Vrachatis,Gerasimos Siasos,Konstantinos Kalogeras,Evangelia Bei,Carmen Moldovan,Maria Lavda,Konstantinos Aznaouridis,Evangelos Oikonomou,Dimitris Tousoulis
标识
DOI:10.2174/0929867322666150630141035
摘要
Inflammation plays a critical role in the atherosclerotic process in various vascular beds, starting from endothelial dysfunction and counting all stages of plaque development. The significant contribution of inflammation in the initiation and progression of atherosclerosis has been documented over many years but its contribution to the development of other cardiovascular disease remains unclear. Inflammatory process constitutes a basic part of pathogenic cascade of aortic diseases including those of aortic valve stenosis and aortic aneurysms. Thus, both of these entities are related with high rates of morbidity and mortality. Therefore, the need to detect and investigate indices representative of inflammation that will be easily measured and may reflect the process of these diseases, is mandatory. However, such biomarkers for aortic diseases that could have a significant prognostic value on survival via the early identification of high risk patients, in general, remain few. Therefore, the illumination of role of such biomarkers, will facilitate the understanding of the mechanisms in molecular and/or cellular level that are responsible for the creation of aortic disease. Such an approach may provide a pathophysiological basis for early diagnosis. Keywords: Aortic aneurysm, aortic disease, aortic dissection, aortic stenosis, biomarkers.
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