神经炎症
胰岛素抵抗
内分泌学
内科学
食欲素-A
蛋白激酶B
神经营养因子
胰岛素受体
海马体
海马结构
p38丝裂原活化蛋白激酶
脑源性神经营养因子
胰岛素
生物
医学
信号转导
炎症
细胞生物学
增食欲素
受体
MAPK/ERK通路
神经肽
作者
Yanyan Ji,Xinsong Lang,Wei Wang,Shengnan Li,Can Zhao,Xue Shen,Tiehua Zhang,Haiqing Ye
出处
期刊:Food & Function
[The Royal Society of Chemistry]
日期:2021-01-01
卷期号:12 (18): 8728-8737
被引量:10
摘要
Long-term consumption of a high-fat diet (HFD) can cause glucose and lipid metabolism disorders, damage the brain and nervous system and result in cognitive impairment. The objective of this study was to investigate the preventative effects of Lactobacillus paracasei (Jlus66, a probiotic extracted from cheese in Northeast China) on cognitive impairment associated with HFD. The water maze was used to compare memory changes in mice fed HFD with or without Jlus66. Hippocampal tissue morphology was examined using H&E staining. The expression of neurotrophic factors BDNF, PSD95 and SNAP25, insulin resistance related proteins IRS-1, AKT and GSK3β, and inflammatory related proteins JNK and p38 were detected using western blotting. The results showed that Jlus66 significantly increased the expression of BDNF, PSD95 and SNAP25 (p < 0.01, respectively), increased expression of p-AKT (p < 0.05), p-IRS-1Y612 and p-GSK3β (p < 0.01, respectively), and reduced the expression of p-IRS-1S307, p-JNK and p-p38 (p < 0.05) compared with the HFD group. We conclude that Jlus66 can ameliorate cognitive impairment via insulin signaling and neuroinflammation pathways.
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