医学
胰腺炎
糖尿病
急性胰腺炎
病理生理学
自身免疫
胰腺
内科学
炎症
胃肠病学
内分泌学
疾病
作者
Dhiraj Yadav,David C. Whitcomb,Gong Tang,Adam Slivka,Melena D. Bellin
标识
DOI:10.1016/j.cgh.2021.11.011
摘要
Pancreatogenic diabetes mellitus, also termed type 3c diabetes (T3cD), or glucose intolerance develops in 25%-75% of adults with chronic pancreatitis (CP). The primary pathophysiologic defect in T3cD is insulin deficiency, thought to result largely from "bystander" injury to the islets from fibrotic changes in the exocrine pancreas and cytokine-induced beta cell dysfunction from intrapancreatic inflammation.1.
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