Microswimmer-based electrochemical platform with active capturer/signal amplifier/funnel-type device for whole blood detection

To effectively detect trace disease markers in whole blood is still a great challenge. Here, a separated capture-detection electrochemical detection platform based on active capture capability/signal amplifier/funnel-type detection device is proposed. Firstly, Mg-based microswimmers modified with magnetic nanomaterials (Mg/ferric oxide/polydopamine/heparin, Mg/Fe3O4/PDA/Hep) are prepared, which can react with water to produce hydrogen as the driving source and Mg2+ as the signal amplifier to cyclically cut the Mg2+-induced nucleic acid fragment. Secondly, the Mg-based microswimmer gradually consumed the Mg microsphere and left the magnetic nanomaterials containing the trapping agent, which can be completely recovered by the magnetic electrode. Finally, the funnel-type electrochemical detection device was applied to fully collect the recognizer for detection in milliliter solution. This strategy can be expected to provide a candidate approach for the early and accurate diagnosis of diseases.