尼氏体
白质
神经科学
方向(向量空间)
生物
建筑
计算机科学
染色
解剖
磁共振成像
地理
医学
遗传学
放射科
考古
数学
几何学
作者
Roey Schurr,Aviv Mezer
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2021-11-05
卷期号:374 (6568): 762-767
被引量:20
标识
DOI:10.1126/science.abj7960
摘要
Uncovering the architecture of white matter axons is fundamental to the study of brain networks. We developed a method for quantifying axonal orientations at a resolution of ~15 micrometers. This method is based on the common Nissl staining technique for postmortem histological slices. Nissl staining reveals the spatial organization of glial cells along axons. Using structure tensor analysis, we leveraged this patterned organization to uncover local axonal orientation. We used Nissl-based structure tensor analysis to extract fine details of axonal architecture and demonstrated its applicability in multiple datasets of humans and nonhuman primates. Nissl-based structure tensor analysis can be used to compare fine-grained features of axonal architecture across species and is widely applicable to existing datasets.
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