变性(裂变材料)
氯化胍
化学
蛋白质折叠
生物物理学
蛋白质二级结构
蛋白质结构
尿素
结晶学
折叠(DSP实现)
蛋白质三级结构
螺旋(腹足类)
生物化学
生物
酶
电气工程
工程类
生态学
核化学
蜗牛
作者
Vaishali A Acharya,Pratima Chaudhuri
出处
期刊:International journal of pharmaceutical sciences review and research
[Global Research Online]
日期:2021-08-15
卷期号:69 (2)
被引量:1
标识
DOI:10.47583/ijpsrr.2021.v69i02.002
摘要
Denaturation of protein is a biological phenomenon in which a protein loses its native shape due to the breaking or disruption of weak chemical bonds and interactions which makes the protein biologically inactive. It is the process where properly folded proteins formed under physiological conditions is transformed to an unfolded protein under non-physiological conditions. The process of denaturation of proteins can occur under different physiological and chemical conditions. Denaturation can be reversible or irreversible. Denaturation mostly takes places when the protein is subjected under external elements like inorganic solutes, organic solvents, acids or bases, and by heat or irradiations. The denaturing agents or denaturants widely used in protein folding or unfolding experiments are urea and guanidinium chloride (GdmCl). In denaturation, the alpha-helix structure and beta sheets structure of the native protein are disrupted and unfolds it into any random shape. We can also say that denaturation occurs due to the disruption of bonding interactions which are responsible for secondary structure and the tertiary structure of the proteins.
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