镉
生物
氧化应激
代谢途径
异型生物质的
谷胱甘肽
环境化学
抗氧化剂
作者
Huan Liu,Huanjun Li,Xiuzhen Zhang,Xianghong Gong,Dianfeng Han,Zhang Huawei,Xiuhui Tian,Yingjiang Xu
标识
DOI:10.1016/j.etap.2021.103683
摘要
Abstract The biological processes of Chlamys farreri (C. farreri), an economically important shellfish, are affected when exposed to Cd2+. In this study, changes to biological processes and metabolite levels in C. farreri were examined when exposed to Cd2+. Ultra-performance liquid chromatography-tandem TOF mass spectrometry (UPLC-TOF/MS)-based untargeted metabolomics was used to examine changes in the metabolism of C. farreri gill tissue exposed to 0.050 mg/L Cd2+ for 96 h in a natural environment. Sixty-eight metabolites with significant differences were screened by multivariate statistical analysis. Eleven enriched functional pathways displayed significant changes in inactivity. Differential metabolites, mainly C00157 and C00350, have a significant impact on functional pathways and can be used as potential major biomarkers. Lipid phosphorylation, disruption of signal transduction, and autophagy activation were observed to change in C. farreri when exposed to Cd. The metabolome information supplements research on C. farreri exposure to heavy metals and provides a platform for further multi-omics analysis.
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