银屑病
中医药
作用机理
机制(生物学)
系统药理学
MAPK/ERK通路
PI3K/AKT/mTOR通路
信号通路
基因
信号转导
药理学
医学
计算生物学
生物
遗传学
药品
免疫学
替代医学
认识论
哲学
病理
体外
作者
Xiaolei Ma,Yinan Lu,Yang Lü,Zhili Pei
出处
期刊:Current Bioinformatics
[Bentham Science]
日期:2021-09-14
卷期号:16 (6): 829-845
标识
DOI:10.2174/1574893616666210315093639
摘要
Background: Tufuling Qiwei Tangsan (TQTS) is a commonly used Mongolian medicine preparation against psoriasis in China. However, its mechanism of action and molecular targets for the treatment of psoriasis is still unclear. Network pharmacology can reveal the synergistic mechanism of drugs at the molecular, target, and pathway levels and is suitable for the complex study of traditional Chinese medicine formulations. However, it is rarely involved in the application of Mongolian medicine with the same holistic concept of traditional Chinese medicine. Method: In this paper, the active compounds of TQTS were collected, and their targets were identified. Psoriasis-related targets were obtained by analyzing the differential expressed genes between psoriasis patients and healthy individuals. Then, the network concerning the interactions of potential targets of TQTS with well-known psoriasis-related targets was built. The core targets were selected according to topological parameters. And the enrichment analysis was carried out to explore the mechanism of action of TQTS. Moreover, molecular docking was performed to study the interaction between the selected ligands and receptors related to psoriasis. Result and Conclusion: Eighty-five active compounds of TQTS were screened, with corresponding 270 targets, and 313 differentially expressed genes were identified. Additionally, enrichment analysis showed that the targets of TQTS for treating psoriasis were mainly involved in multiple biological processes, including apoptosis, growth factor response, etc., and related pathways including PI3K-Akt and MAPK signaling pathway, and so on. Genes such as NFKB1, TP53, and MAPK1 are the key genes in the gene pathway network of TQTS against psoriasis. The 4 main active components of TQTS have certain binding activity with 13 potential targets, and the stability of their interaction with AKT1 is found to be the most efficient, which indicates the potential mechanism of TQTS on psoriasis.
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