FGF1型
细胞内
细胞生物学
成纤维细胞生长因子
生物
功能(生物学)
受体
成纤维细胞生长因子受体
生物化学
作者
Katarzyna Dominika Sluzalska,Jakub Sławski,Martyna Sochacka,Agata Lampart,Jacek Otlewski,Małgorzata Zakrzewska
标识
DOI:10.1016/j.cytogfr.2020.05.004
摘要
Fibroblast growth factors 1 and 2 (FGF1 and FGF2) are mainly considered as ligands of surface receptors through which they regulate a broad spectrum of biological processes. They are secreted in non-canonical way and, unlike other growth factors, they are able to translocate from the endosome to the cell interior. These unique features, as well as the role of the intracellular pool of FGF1 and FGF2, are far from being fully understood. An increasing number of reports address this problem, focusing on the intracellular interactions of FGF1 and 2. Here, we summarize the current state of knowledge of the FGF1 and FGF2 binding partners inside the cell and the possible role of these interactions. The partner proteins are grouped according to their function, including proteins involved in secretion, cell signaling, nucleocytoplasmic transport, binding and processing of nucleic acids, ATP binding, and cytoskeleton assembly. An in-depth analysis of the network of these binding partners could indicate novel, non-classical functions of FGF1 and FGF2 and uncover an additional level of a fine control of the well-known FGF-regulated cellular processes.
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