医学
胰十二指肠切除术
胰腺
内分泌系统
胰管
胃肠病学
内科学
B组
胰腺癌
癌症
激素
作者
Hye Jeong Yoon,Jeong Sik Choi,Woo Young Shin,Keon-Young Lee,Seung-Ik Ahn
出处
期刊:Pancreas
[Ovid Technologies (Wolters Kluwer)]
日期:2020-03-01
卷期号:49 (3): 368-374
标识
DOI:10.1097/mpa.0000000000001492
摘要
Objectives It is unclear whether the improved glucose metabolism in pancreas head cancer (PHC) patients after pancreaticoduodenectomy is due to the anatomical change or the relief of pancreatic duct obstruction. Methods We divided 170 patients into the PHC group (n = 54, 31.8%) and other pathology (non-PHC) group (n = 116, 68.2%). Glucose metabolic function was evaluated using the glucose tolerance index (GTI), and the pancreatic duct obstruction and dilatation was measured using the pancreatic atrophic index (PAI). Results The preoperative GTI was significantly higher in the PHC group (mean [standard deviation {SD}], 0.84 [1.16]) than in the non-PHC group (0.41 [SD, 0.59], P = 0.000). The postoperative GTI decreased significantly in the PHC group but remained unchanged in the non-PHC group. Similarly, the preoperative PAI was higher in the PHC group (0.32 [SD, 0.19]) than in the non-PHC group (0.13 [SD, 0.09], P = 0.000). The postoperative PAI decreased significantly in the PHC group, but not in the non-PHC group. Conclusions The impaired glucose metabolism in PHC can be caused by pancreatic duct obstruction. After pancreaticoduodenectomy, glucose metabolism is improved by the relief of pancreatic duct obstruction, and not by the anatomical change. The patients should be counseled accordingly.
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