白藜芦醇
化学
神经保护
萜类
多酚
生物利用度
药理学
抗氧化剂
传统医学
生物化学
医学
作者
Qing Shan Li,Yao Li,Girdhar Singh Deora,Ban Feng Ruan
出处
期刊:Mini-reviews in Medicinal Chemistry
[Bentham Science]
日期:2019-05-29
卷期号:19 (10): 809-825
被引量:21
标识
DOI:10.2174/1389557519666190128093840
摘要
Resveratrol is a non-flavonoid polyphenol containing a terpenoid backbone. It has been intensively studied because of its various promising biological properties, such as anticancer, antioxidant, antibacterial, neuroprotective and anti-inflammatory activities. However, the medicinal application of resveratrol is constrained by its poor bioavailability and stability. In the past decade, more attention has been focused on making resveratrol derivatives to improve its pharmacological activities and pharmacokinetics. This review covers the literature published over the past 15 years on synthetic analogues of resveratrol. The emphasis is on the chemistry of new compounds and relevant biological activities along with structure-activity relationship. This review aims to provide a scientific and reliable basis for the development of resveratrol-based clinical drugs.
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