光热治疗
纳米颗粒
药物输送
金属有机骨架
纳米技术
阿霉素
化学工程
辐照
体内
活性氧
材料科学
化学
有机化学
吸附
医学
化疗
核物理学
生物化学
物理
生物
生物技术
外科
工程类
作者
Dan Yang,Jiating Xu,Guixin Yang,Yuan Zhou,Hongjiao Ji,Huiting Bi,Shili Gai,Fei He,Piaoping Yang
标识
DOI:10.1016/j.cej.2018.03.101
摘要
Developing multifunctional drug delivery systems for achieving the combination of diagnosis and treatment is highly desirable due to the improved therapeutic effect and minimized side effects. Metal-organic frameworks (MOFs) as emerging porous materials exhibit many intriguing properties for application in biomedicine. Here, MOFs coated up-conversion nanoparticles (UCNPs) were synthesized by a facile one-pot liquid-solid-solution (LSS) method for the first time. The encapsulation of UCNPs into MIL-100(Fe) shell leads to core-shell structured [email protected](Fe) NPs. Upon 808 nm laser irradiation, the sample produces abundant reactive oxygen species (ROS) of hydroxyl radical (OH) in the presence of H2O2 derived from Fenton reaction, which are highly toxic to tumor cells. Meanwhile, the MIL-100(Fe) shell efficiently converts the excited laser energy into heat, thus achieving apparent photothermal therapy (PTT) effect. Furthermore, the porous structure and high specific area of the MOFs shell make it possible to load large amount of toxic doxorubicin (DOX). In vivo and in vitro results indicate that DOX loaded [email protected](Fe) NPs markedly suppress the tumor cell growth under very mild 808 nm laser irradiation (0.5 W/cm2) based on synergistic (photodynamic, photothermal, and chemo-therapy) effect. This study presents a feasible strategy for developing multifunctional drug delivery system based on MOFs that are responsive to high-penetrated 808 nm laser.
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