黑色素瘤
生物
线粒体
谷氨酰胺分解
癌症研究
表观遗传学
基因
癌症
生物信息学
计算生物学
细胞生物学
遗传学
癌细胞
作者
Christina Huang,Rakan Radi,Jack L. Arbiser
出处
期刊:Cells
[MDPI AG]
日期:2021-11-16
卷期号:10 (11): 3197-3197
被引量:9
标识
DOI:10.3390/cells10113197
摘要
Melanoma and its associated alterations in cellular pathways have been growing areas of interest in research, especially as specific biological pathways are being elucidated. Some of these alterations include changes in the mitochondrial metabolism in melanoma. Many mitochondrial metabolic changes lead to differences in the survivability of cancer cells and confer resistance to targeted therapies. While extensive work has gone into characterizing mechanisms of resistance, the role of mitochondrial adaptation as a mode of resistance is not completely understood. In this review, we wish to explore mitochondrial metabolism in melanoma and how it impacts modes of resistance. There are several genes that play a major role in melanoma mitochondrial metabolism which require a full understanding to optimally target melanoma. These include BRAF, CRAF, SOX2, MCL1, TRAP1, RHOA, SRF, SIRT3, PTEN, and AKT1. We will be discussing the role of these genes in melanoma in greater detail. An enhanced understanding of mitochondrial metabolism and these modes of resistance may result in novel combinatorial and sequential therapies that may lead to greater therapeutic benefit.
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