气凝胶
纳米纤维
材料科学
明胶
生物相容性
静电纺丝
伤口愈合
复合材料
医学
化学
外科
生物化学
冶金
聚合物
作者
Zhenyang Mao,Jiarun Bai,Xuefeng Jin,Wenwei Mao,Yan Dong
标识
DOI:10.1016/j.colsurfb.2021.112070
摘要
Bacterial infection and severe wound inflammation are two primary harmful problems that bring harm to the human body and may cause death when a large-scale skin defect occurs. Thus, developing an effective and quick wound healing strategy for curing skin damage and trauma is vital. This study has developed a multifunctional PLA/gelatin/ZnO nanofiber aerogel with a three-dimensional structure through electrospinning and freeze-drying technology for wound healing. It has validated that the nanofiber aerogel has an excellent antibacterial property and biocompatibility. Meanwhile, benefiting from its three-dimensional nanofiber structure, the PLA/gelatin/ZnO nanofiber aerogel possesses good water absorption and air permeability. In vivo experiments have determined that the PLA/gel/ZnO nanofiber aerogel scaffolds effectively promote skin infection’s wound healing and enhance angiogenesis that is practical with increasing ZnO concentration.
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