Efficient degradation and detoxification of antibiotic Fosfomycin by UV irradiation in the presence of persulfate

Fosfomycin (FOS) as a widely used antibiotic has been found in abundance throughout the environment, but little effort has been devoted to its treatment. In this study, we systemically looked into the degradation of FOS by ultraviolet-activated persulfate (UV/PS) in aqueous solutions. Our findings demonstrated that FOS can be degraded efficiently under the UV/PS, e.g., >90 % of FOS was degraded with 19,200 mJ cm-2 of UV irradiance and 20 μM of PS. HO was the dominant radical responsible for FOS degradation. FOS degradation increased as PS dosage increased, and higher degradation efficiency was observed at neutral pH. Natural water constitutes either promoted (e.g., Cu2+, Fe3+, and SO42-) or inhibited (e.g., humic acid, HCO3-, and CO32-) FOS degradation to varying degrees. Hydroxyl substitution, CP bond cleavage, and coupling reactions were the major degradation pathways for FOS degradation. Finally, the toxicity evaluation revealed that FOS was toxic to E. coli and S. aureus, but the toxicity of the intermediate products of FOS to E. coli and S. aureus rapidly decreased over time after UV/PS treatment. Therefore, these findings provided a fundamental understanding of the transformation process of FOS and supplied useful information for the environmental elimination of FOS contamination and its toxicity.