Photosynthesis‐Inspired NIR‐Triggered Fe₃O₄@MoS₂ Core–Shell Nanozyme for Promoting MRSA‐Infected Diabetic Wound Healing

Abstract Bacterial infections can lead to severe medical complications, including major medical incidents and even death, posing a significant challenge in clinical trauma repair. Consequently, the development of new, efficient, and non‐resistant antimicrobial agents has become a priority for medical practitioners. In this study, a stepwise hydrothermal reaction strategy is utilized to prepare Fe 3 O 4 @MoS 2 core–shell nanoparticles (NPs) with photosynthesis‐like activity for the treatment of bacterial infections. The Fe 3 O 4 @MoS 2 NPs continuously catalyze the production of reactive oxygen species (ROS) from hydrogen peroxide through photosynthesis‐like reactions and convert light energy into heat with a photothermal efficiency of 30.30%. In addition, the photosynthetically generated ROS, combined with the iron‐induced cell death mechanism of the Fe 3 O 4 @MoS 2 NPs, confer them with exceptional and broad‐spectrum antibacterial properties, achieving antimicrobial activities of up to 98.62% for Staphylococcus aureus , 99.22% for Escherichia coli , and 98.55% for methicillin‐resistant Staphylococcus aureus . The composite exhibits good cell safety and hemocompatibility. Finally, a full‐thickness diabetic wound model validates the significant pro‐healing properties of Fe 3 O 4 @MoS 2 in chronic diabetic wounds. Overall, the design of photosynthesis‐inspired Fe 3 O 4 @MoS 2 presents new perspectives for developing efficient photothermal nano‐enzymatic compounds, offering a promising solution to the challenges of antimicrobial drug resistance and antibiotic misuse.