光敏剂
光动力疗法
光热治疗
活性氧
氧化应激
化学
光子上转换
光化学
免疫原性细胞死亡
癌症研究
材料科学
生物物理学
纳米技术
发光
程序性细胞死亡
生物化学
细胞凋亡
光电子学
医学
生物
有机化学
作者
Fengxia Wu,Haoran Chen,Qiqing Li,Ruiqi Liu,Yang Suo,Bin Li,Xianggui Kong,Zhen Cheng,Hongguang Liu,Yulei Chang
标识
DOI:10.1016/j.cej.2023.143827
摘要
Reactive oxygen species (ROS) are closely related to innate and adaptive immune responses in tumor immunotherapy. ROS-mediated therapies show great hope in improving therapeutic efficacy by inducing immunogenic cell death. However, the efficiency is still limited by the poor ROS production rate. Herein, a ROS nanogenerator is designed to boost antitumor immunity, integrating with pH-dissociable Fe3+-gallic acid (Fe-GA) complex as the shell and photosensitizer (Chlorin e6, Ce6)-coupled lanthanide-doped luminescence nanoparticles (LnNPs) as the core. Upon near-infrared (NIR) light irradiation, LnNPs exhibit multiband upconversion emission from ultraviolet (UV) to visible (Vis) and downshifting emission in the promising second NIR imaging region (NIR-II, 1550 nm). Especially, the UV photons and reducing agent GA could respectively mediate the reduction of Fe3+, allowing more Fe2+ to participate in the Fenton reaction to generate hydroxyl radicals (•OH) for ferroptosis therapy (FT). Besides, the UV–Vis upconversion emission can activate the coupling photosensitizer-Ce6 to generate 1O2 for photodynamic therapy (PDT). Additionally, Fe-GA can serve as a photothermal therapy (PTT) agent; in turn, hyperthermia enhances ROS generation. Our rational-designed Ln@Fe NPs could not only enhance the synergistic antitumor efficiency by boosting ROS generation but also effectively inhibit tumor metastasis by activating strong antitumor immunity, providing a paradigm for imaging-guided cancer treatment.
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