医学
气压感受器
去神经支配
心脏病学
肺动脉
血管收缩
血流动力学
内科学
肺动脉高压
交感神经系统
缺氧性肺血管收缩
血压
麻醉
心率
作者
Manasi Tannu,Richard A. Krasuski
标识
DOI:10.1016/j.iccl.2023.03.005
摘要
Pulmonary arterial hypertension (PAH) is a progressive, life-limiting disease. Despite significant medical progress over the last three decades, the prognosis of PAH remains poor. PAH is associated with sympathetic nervous system over-stimulation and baroreceptor-mediated vasoconstriction, leading to pathologic pulmonary artery (PA) and right ventricular remodeling. PA denervation is a minimally-invasive intervention that ablates local sympathetic nerve fibers and baroreceptors to modulate pathologic vasoconstriction. Preliminary animal and clinical studies have shown improvements in short-term pulmonary hemodynamics and PA remodeling. However, future studies are needed to elucidate appropriate patient selection, timing of intervention, and long-term efficacy before integration into standard of care.
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