对偶(语法数字)
化学
催化作用
铜
组合化学
光催化
双重角色
有机化学
光化学
艺术
文学类
光催化
作者
Yuxin Fan,Zhonghou Huang,Yi Lü,Shuai Zhu,Lingling Chu
标识
DOI:10.1002/anie.202315974
摘要
A regioselectivity reversed three-component defluorinative alkylboration of alkenes with trifluoromethyls and bis(pinacolato)diboron via dual photoredox/copper catalysis is reported. The mild conditions are compatible with a wide array of nonactivated trifluoromethyl aromatics bearing electron-donating or electron-neutral substituents, trifluoroacetamides, and various nonactivated terminal and internal alkenes, enabling straightforward access to synthetically valuable γ-gem-difluoroalkyl boronates with high efficiency. Furthermore, this protocol is applicable to alkene-tethered trifluoromethyl aromatics to furnish gem-difluoromethylene-containing cyclic compounds. Synthetic applications and preliminary mechanistic studies are also presented.
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