细胞生物学
基底膜
再生(生物学)
炎症
干细胞
生物
细胞
利基
免疫学
遗传学
生物化学
作者
Nabora S. Reyes,Maria Krasilnikov,Nancy C. Allen,Jin Young Lee,Ben Hyams,Minqi Zhou,Supriya Ravishankar,Monica Cassandras,Chaoqun Wang,Imran S. Khan,Peri Matatia,Yoshikazu Johmura,Ari B. Molofsky,Michael A. Matthay,Makoto Nakanishi,Dean Sheppard,Judith Campisi,Tien Peng
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2022-10-14
卷期号:378 (6616): 192-201
被引量:53
标识
DOI:10.1126/science.abf3326
摘要
We engineered an ultrasensitive reporter of p16INK4a, a biomarker of cellular senescence. Our reporter detected p16INK4a-expressing fibroblasts with certain senescent characteristics that appeared shortly after birth in the basement membrane adjacent to epithelial stem cells in the lung. Furthermore, these p16INK4a+ fibroblasts had enhanced capacity to sense tissue inflammation and respond through their increased secretory capacity to promote epithelial regeneration. In addition, p16INK4a expression was required in fibroblasts to enhance epithelial regeneration. This study highlights a role for p16INK4a+ fibroblasts as tissue-resident sentinels in the stem cell niche that monitor barrier integrity and rapidly respond to inflammation to promote tissue regeneration.
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