C-type lectin receptor LSECtin-mediated apoptotic cell clearance by macrophages directs intestinal repair in experimental colitis

Significance The clearance of apoptotic cells is critical for maintaining tissue homeostasis, and myeloid C-type lectin receptors (CLRs) may be prominently involved in the clearance of dying cells and their debris. Here, we report that the CLR member LSECtin is expressed on macrophages, which are engaged in corpse clearance. This engulfment progress by macrophages through LSECtin is critical for intestinal healing. Loss of LSECtin promotes dextran sulfate sodium-induced colitis due to unrepaired intestinal epithelium. These results indicate that corpse clearance by macrophages can direct intestinal regeneration. These findings advance understanding of how homeostasis is maintained within the mucosa.