生物
表皮系统
再生医学
再生(生物学)
器官系统
诱导多能干细胞
干细胞
器官发生
发育生物学
干细胞生物学
胚胎干细胞
细胞生物学
神经科学
解剖
病理
胚胎
胚胎发生
遗传学
医学
生殖技术
基因
疾病
作者
Makoto Takeo,Takashi Tsuji
标识
DOI:10.1016/j.gde.2018.05.008
摘要
In this decade, great progress has been made in the field of organ regeneration by incorporating emerging concepts from the fields of stem cell biology and developmental biology, and this progress has pioneered a new frontier in regenerative medicine. The generation of bioengineered organ germ-utilizing, fate-determined, organ-inductive epithelial and mesenchymal cells has provided evidence for the concept of functional organ regeneration in vivo. Organoid studies have verified that nearly all organs can be generated in the form of a mini-organ by recapitulating embryonic body patterning and establishing an organ-forming field among self-organizing pluripotent stem cells by utilizing cytokines that mimic the patterning and positional signals of organogenesis. More recently, the regeneration of an integumentary organ system composed of multiple organs, including hair follicles, has been achieved, demonstrating that regenerative medicine is forthcoming. In this review, we will introduce current research trends aimed at regenerating a functional three-dimensional (3D) organ, and we will discuss the potential use of these recent achievements and future directions needed to realize the next-generation of regenerative therapy for organ replacement.
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