生物
丁酸盐
微生物群
背景(考古学)
代谢物
拟杆菌
拉伤
聚糖
遗传学
肠道菌群
计算生物学
生物化学
细菌
糖蛋白
古生物学
解剖
发酵
作者
Sun-Yang Park,Chitong Rao,Katharine Z. Coyte,Gavin A. Kuziel,Yancong Zhang,Wentao Huang,Eric A. Franzosa,Jing‐Ke Weng,Curtis Huttenhower,Seth Rakoff-Nahoum
出处
期刊:Cell
[Elsevier]
日期:2022-02-01
卷期号:185 (3): 513-529.e21
被引量:30
标识
DOI:10.1016/j.cell.2022.01.002
摘要
The human gut microbiota resides within a diverse chemical environment challenging our ability to understand the forces shaping this ecosystem. Here, we reveal that fitness of the Bacteroidales, the dominant order of bacteria in the human gut, is an emergent property of glycans and one specific metabolite, butyrate. Distinct sugars serve as strain-variable fitness switches activating context-dependent inhibitory functions of butyrate. Differential fitness effects of butyrate within the Bacteroides are mediated by species-level variation in Acyl-CoA thioesterase activity and nucleotide polymorphisms regulating an Acyl-CoA transferase. Using in vivo multi-omic profiles, we demonstrate Bacteroides fitness in the human gut is associated together, but not independently, with Acyl-CoA transferase expression and butyrate. Our data reveal that each strain of the Bacteroides exists within a unique fitness landscape based on the interaction of chemical components unpredictable by the effect of each part alone mediated by flexibility in the core genome.
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