化学
色谱法
化学电离
质谱法
电子电离
气相色谱法
萃取(化学)
气相色谱-质谱法
固相萃取
气相色谱/串联质谱法
串联质谱法
环境化学
电离
离子
有机化学
作者
Romina Pozzi,Paola Bocchini,Francesca Pinelli,Guido C. Galletti
标识
DOI:10.1016/j.chroma.2011.02.009
摘要
A gas chromatography/mass spectrometry (GC/MS) method for determination of nine N-nitrosamines (NAs) in water is described. Two ionization modes, electron impact (EI) and chemical ionization (CI) with methanol, as well as different ion analysis techniques, i.e. full scan, selected ion storage (SIS) and tandem mass spectrometry (MS/MS) were tested. Chemical ionization followed by SIS resulted the mass spectrometric method of choice, with detection limits in the range of 1–2 ng/L. Solid Phase Extraction (SPE) with coconut charcoal cartridges was applied to extract NAs from real samples, according EPA Method 521. Drinking water samples were collected from seven surface- and two groundwater treatment plants. Three surface water treatment plants were sampled before and after addition of O3/ClO2 to observe the effect of disinfection on NAs’ formation. N-nitrosodiethylamine (NDEA), n-nitrosodipropylamine (NDPA), n-nitrosomorpholine (NMOR) and n-nitrosodibutylamine (NDBA) were found up to concentrations exceeding three times the risk level of 10 ng/L set by the California Department of Public Health. Because dermal adsorption has been recently indicated as a new contamination route of exposure to NAs for people who practice swimming activity, water samples from five swimming pools in the Bologna (Italy) area were collected. N-nitrosopyrrolidine (NPYR) was detected in all samples at concentrations larger than 50 ng/L, likely as a disinfection by-product from the amino acid precursor proline, a main constituent of skin collagen.
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