安普克
绞股蓝
化学
蛋白激酶A
达玛烷
AMP活化蛋白激酶
脂质代谢
过剩4
生物化学
激酶
染色体易位
萃取(化学)
替代医学
病理
基因
医学
色谱法
三萜
作者
Phi Hùng Nguyễn,Gauhar Rehman,Seung Lark Hwang,Trọng Tuấn Đào,Dong Chan Park,Ji Eun Kim,Hebok Song,Tae Lin Huh,Won Keun Oh
标识
DOI:10.1016/j.bmc.2011.09.013
摘要
AMP-activated protein kinase (AMPK) is a key sensor and regulator of glucose, lipid, and energy metabolism throughout the body. Activation of AMPK improves metabolic abnormalities associated with metabolic diseases including obesity and type-2 diabetes. The oriental traditional medicinal herbal plant, Gynostemma pentaphyllum, has shown a wide range of beneficial effects on glucose and lipid metabolism. In this study, we found that G. pentaphyllum contains two novel dammarane-type saponins designated as damulin A (1), 2α,3β,12β–trihydroxydammar-20(22)-E,24-diene-3-O-[β-d-glucopyranosyl-(1→2)-β-d-glucopyranoside], and damulin B (2), 2α,3β,12β-trihydroxydammar-20,24-diene-3-O-[β-d-glucopyranosyl-(1→2)-β-d-glucopyranoside], that strongly activate AMPK in cultured L6 myotube cells. Damulins A and B also increased β-oxidation and glucose uptake with increasing GluT4 translocation to the plasma membrane in L6 myotube cells. Taken together our results indicate that activation of AMPK by damulins A and B may contribute to beneficial effect of G. pentaphyllum on glucose and lipid metabolism.
科研通智能强力驱动
Strongly Powered by AbleSci AI