Actinic granuloma occurring in an unusual association with cutaneous B‐cell chronic lymphocytic leukemia

Granulomatous cutaneous reactions are well described in association with T‐cell non‐Hodgkin lymphoma and Hodgkin lymphoma, but are rarely seen in association with B‐cell non‐Hodgkin lymphoma or leukemia. We report a case of a 65‐year‐old woman with B‐cell chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) who presented with multiple, tender, firm pink papules on the face, upper trunk and upper extremities 6 years after diagnosis of CLL. Biopsy revealed both palisading granulomatous dermatitis consistent with actinic granuloma and a dense perivascular lymphocytic infiltrate consistent with the patient's known history of leukemia. This is an unusual manifestation of cutaneous B‐cell CLL that is rarely seen. Kauffman JA, Ivan DS, Cutlan JE, Hymes SR. Actinic granuloma occurring in an unusual association with cutaneous B‐cell chronic lymphocytic leukemia.