先天免疫系统
补体系统
经典补体途径
补体受体
免疫系统
生物
免疫学
炎症
获得性免疫系统
替代补体途径
效应器
免疫
补语(音乐)
补体成分3
补体膜攻击复合物
细胞生物学
表型
遗传学
基因
互补
作者
Leendert A. Trouw,Mohamed R. Daha
标识
DOI:10.1016/j.imlet.2011.02.014
摘要
The complement system is an important part of the innate immune defense. Next to its role as an effector mechanism of the innate immune system, complement also plays a major role in shaping the adaptive immune response. The complement system is also involved in several other physiological processes such as tissue regeneration and clearance of immune complexes and dead cells. Unfortunately complement is also involved in pathology by contributing to tissue damage, induction of autoimmune reactions and chronic inflammation. Tight regulation of complement activation by both fluid-phase and membrane bound complement inhibitors is essential to maintain a good balance between optimal protection with as little as possible damage to the host. Alterations in this balance and hence the function of complement, by influence of auto-antibodies, or genetic variants, may render the complement system into a harmful player in tissue damage and pathology.
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