CD8型
免疫系统
免疫疗法
双歧杆菌
启动(农业)
肿瘤微环境
T细胞
生物
癌症研究
免疫检查点
免疫学
树突状细胞
癌症免疫疗法
过继性细胞移植
黑色素瘤
免疫
乳酸菌
细菌
发芽
植物
遗传学
作者
Ayelet Sivan,Leticia Corrales,Nathaniel Hubert,Jason Williams,Keston Aquino‐Michaels,Zachary M. Earley,Franco W. Benyamin,Yuk Man Lei,Bana Jabrì,Maria‐Luisa Alegre,Eugene B. Chang,Thomas F. Gajewski
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2015-11-27
卷期号:350 (6264): 1084-1089
被引量:2706
标识
DOI:10.1126/science.aac4255
摘要
T cell infiltration of solid tumors is associated with favorable patient outcomes, yet the mechanisms underlying variable immune responses between individuals are not well understood. One possible modulator could be the intestinal microbiota. We compared melanoma growth in mice harboring distinct commensal microbiota and observed differences in spontaneous antitumor immunity, which were eliminated upon cohousing or after fecal transfer. Sequencing of the 16S ribosomal RNA identified Bifidobacterium as associated with the antitumor effects. Oral administration of Bifidobacterium alone improved tumor control to the same degree as programmed cell death protein 1 ligand 1 (PD-L1)-specific antibody therapy (checkpoint blockade), and combination treatment nearly abolished tumor outgrowth. Augmented dendritic cell function leading to enhanced CD8(+) T cell priming and accumulation in the tumor microenvironment mediated the effect. Our data suggest that manipulating the microbiota may modulate cancer immunotherapy.
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