遗尿
水通道蛋白2
高钙尿症
泌尿系统
内科学
内分泌学
尿
加压素
医学
尿渗透压
夜行的
多尿
泌尿科
尿失禁
水道
工程类
入口
糖尿病
机械工程
作者
Giovanna Valenti,A.F. Laera,G Pace,Gabriella Aceto,M Lospalluti,Philippe Rosa,Francesco Paolo Selvaggi,Maria Laura Chiozza,María Svelto
出处
期刊:Journal of The American Society of Nephrology
日期:2000-10-01
卷期号:11 (10): 1873-1881
被引量:98
标识
DOI:10.1681/asn.v11101873
摘要
Abstract. This study examined the hypothesis that nocturnal enuresis might be paralleled by aquaporin 2 (AQP2) urinary excretion. Eighty children who experienced nocturnal enuresis were studied and compared with 9 healthy children. The 24-h urine samples were divided into two portions: night collections and day collections. Creatinine equivalents of urine samples from each patient were analyzed by Western blotting. AQP2 levels were semiquantified by densitometric scanning and reported as a ratio between the intensity of the signal in the day urine sample versus the night urine sample (D/N AQP2 ratio). The D/N AQP2 ratio was 0.59 ± 0.11 ( n = 9) in healthy children and increased to 1.27 ± 0.24 ( n = 10) in a subpopulation of enuretic children who had low nocturnal vasopressin levels. In enuretic children who displayed hypercalciuria and had normal vasopressin levels, the D/N AQP2 ratio was 1.05 ± 0.27 ( n = 8). These data indicate that reduced secretion of vasopressin and absorptive hypercalciuria are independently associated with an approximately twofold increase in the urinary D/N AQP2 ratio. When low nocturnal vasopressin levels were associated with hypercalciuria, a nearly threefold increase in the D/N AQP2 ratio was observed (1.67 ± 0.41, n = 11). In addition, in all enuretic patients tested, the urinary D/N AQP2 ratio correlates perfectly with the severity of the disorder (nocturnal polyuria). The findings reported in this article indicate that urinary AQP2 correlates with the severity of enuresis in children.
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