传出细胞增多
清道夫受体
泡沫电池
胆固醇
炎症
胆固醇逆向转运
肝X受体
巨噬细胞
平衡
脂蛋白
内分泌学
内科学
生物
受体
细胞生物学
化学
核受体
医学
生物化学
体外
基因
转录因子
作者
MacRae F. Linton,Tao Huan,Edward F Linton,Patricia G. Yancey
标识
DOI:10.1016/j.tem.2017.02.001
摘要
The HDL receptor scavenger receptor class B type I (SR-BI) plays crucial roles in cholesterol homeostasis, lipoprotein metabolism, and atherosclerosis. Hepatic SR-BI mediates reverse cholesterol transport (RCT) by the uptake of HDL cholesterol for routing to the bile. Through the selective uptake of HDL lipids, hepatic SR-BI modulates HDL composition and preserves HDL's atheroprotective functions of mediating cholesterol efflux and minimizing inflammation and oxidation. Macrophage and endothelial cell SR-BI inhibits the development of atherosclerosis by mediating cholesterol trafficking to minimize atherosclerotic lesion foam cell formation. SR-BI signaling also helps limit inflammation and cell death and mediates efferocytosis of apoptotic cells in atherosclerotic lesions thereby preventing vulnerable plaque formation. SR-BI is emerging as a multifunctional therapeutic target to reduce atherosclerosis development.
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