医学
多囊卵巢
不育
促黄体激素
怀孕
焦虑
体质指数
生育率
睾酮(贴片)
生活质量(医疗保健)
女性不育
产科
妇科
内科学
激素
肥胖
人口
胰岛素抵抗
精神科
生物
护理部
环境卫生
遗传学
作者
Duojia Zhang,Jingshu Gao,Huichao Qin,Hui Hua Chang,Xiaoke Wu
摘要
Abstract Aim This work sought to evaluate the correlation between the five domains of the Polycystic Ovary Syndrome Questionnaire (PCOSQ) and anxiety and depression scales and the clinical phenotype and fertility outcomes in infertile polycystic ovary syndrome (PCOS) patients and to determine the effect of quality of life (QOL) on the clinical, biochemical and fertility disorders in these patients. Methods The data in this study came from a large‐scale hospital‐based cohort survey of infertile PCOS patients across mainland China. A total of 1000 infertile PCOS subjects diagnosed according to the modified Rotterdam criteria ranging in age from 20 to 40 years in 21 sub‐centers (27 hospitals) were enrolled. Baseline anthropometric parameters, endocrine indexes, metabolic panel, QOL questionnaires and the fertility outcomes of ovulation, conception, pregnancy, pregnancy loss and live birth were collected. Results PCOSQ scores were significantly correlated with most of the baseline parameters. PCOSQ‐weight domain scores of National Institute of Health‐PCOS group were significantly lower compared with non‐National Institute of Health‐PCOS group. The five domains scores of PCOSQ were significantly negatively correlated with the body mass index levels of PCOS patients. The serum testosterone levels (total testosterone, free testosterone and free androgen index) were significantly negatively correlated to the scores for the weight, body hair, infertility and emotion domains of PCOSQ. Scores on the anxiety and depression scales were significantly and positively correlated with luteinizing hormone, luteinizing hormone/follicle‐stimulating hormone levels. In the low‐score group of infertility domain, the rates of conception, pregnancy and live birth decreased significantly. Conclusions QOL appears to have an impact on the physical symptoms of PCOS, and the emotional stress of infertility affects fertility outcomes.
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