嘧啶
立体化学
细胞毒性
链霉菌
链霉菌科
绝对构型
化学
放线菌
生物
体外
生物化学
细菌
遗传学
作者
Cheng-Dong Xu,Hao-Jian Zhang,Zhongjun Ma
标识
DOI:10.1021/acs.jnatprod.9b00260
摘要
Eleven new pyrimidine nucleosides (1-11) and 12 known analogues (12-23) were isolated from the marine-derived Streptomyces sp. SSA28. All of the new structures were elucidated by extensive NMR spectroscopic analysis and HRESIMS data. The absolute configurations of compound 1 were determined by X-ray diffraction. The configurations of 2-16 were investigated by ECD calculations. Compounds 11-16 showed cytotoxicity against HCT-116 human colon cancer cell lines with IC50 values from 0.39 ± 0.03 to 6.63 ± 0.47 μM.
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