材料科学
纳米技术
木质素
球体
共价键
胶粘剂
聚合
穿孔素
化学工程
复合材料
聚合物
图层(电子)
化学
有机化学
生物化学
物理
细胞毒性T细胞
天文
工程类
体外
作者
Hairong Wang,S.C. Tan,Zhenhua Su,Mingfei Li,Xiang Hao,Feng Peng
标识
DOI:10.1002/adma.202311073
摘要
Abstract Despite the first observations that the perforin can punch holes in target cells for live/dead cycles in the human immune system over 110 years ago, emulating this behaviour in materials science remains challenging. In this study, a perforin‐mimicking molecular drilling strategy is employed to engineer macroporous hollow lignin spheres as performance‐configurable catalysts, adhesives, and gels. Using a toolbox of over 20 molecular compounds, the local curvature of amphiphilic lignin is modulated to generate macroporous spheres with hole sizes ranging from 0–100 nm. Multiscale control is precisely achieved through non‐covalent assembly directing catalysis, synthesis, and polymerization. Exceptional performance mutations correlated with the changes in hole size, including an increase in catalytic efficiency from 50% to 100%, transition from non‐stick synthetics to ultrastrong adhesives (adhesion ∼18.3 MPa, exceeding that of classic epoxies), and transformation of viscous sols to tough nanogels. Thus, this study provides a robust and versatile non‐covalent route for mimicking perforin‐induced structural variations in cells, representing a significant stride towards the exquisite orchestration of assemblies over multiple length scales. This article is protected by copyright. All rights reserved
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