医学
慢性血栓栓塞性肺高压
荟萃分析
内科学
肺栓塞
肺动脉高压
随机对照试验
重症监护医学
作者
Adolfo Martinez Salazar,Gabriel Panama,A. Kim,Supratik Rayamajhi,George S. Abela
标识
DOI:10.1016/j.cpcardiol.2024.102377
摘要
Pulmonary hypertension (PH) is a known chronic condition that can lead to increased morbidity and mortality. Patients who develop PH due to thromboembolic disease are catalogued as chronic thromboembolic pulmonary hypertension (CTEPH). Anticoagulation remains a topic of interest in these patients. PUBMED, EMBASE and COCHRANE databases were searched by two investigators until December 2023. Information was analyzed for all-cause mortality, venous thromboembolism and major bleeding. We included a total of 10 studies in this meta-analysis. Our pooled analysis demonstrated that DOACs were non-inferior in all-cause mortality [OR 0.88, 95% CI (0.48, 1.61)], venous thromboembolism [OR 1.00, 95% CI (0.50, 1.98)] and major bleeding [OR 0.78, 95% CI (0.43, 1.40)] when compared to VKAs. In conclusion, our meta-analysis supports the use of DOACs in patients with CTEPH. Further randomized trials are still needed to confirm our results in terms of safety and mortality
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