胸腺基质淋巴细胞生成素
医学
哮喘
免疫学
细胞因子
临床试验
单克隆抗体
炎症
促炎细胞因子
抗体
内科学
作者
Masaharu Shinkai,Tadataka Yabuta
出处
期刊:Immunotherapy
[Future Medicine]
日期:2023-12-01
卷期号:15 (17): 1435-1447
标识
DOI:10.2217/imt-2023-0079
摘要
Asthma is a common chronic respiratory disease in which epithelial cytokines and airway inflammation play critical pathophysiological roles. Thymic stromal lymphopoietin (TSLP), an epithelial cytokine, is central in the initiation and persistence of airway inflammation in asthma. Tezepelumab is a human immunoglobulin G2λ (IgG2λ) monoclonal antibody developed for treating moderate-to-severe asthma by specifically binding to TSLP and preventing its binding to the TSLP receptor on inflammatory cells. In this narrative review, we describe the results of clinical trials that evaluated the pharmacokinetics, pharmacodynamics, efficacy and safety of tezepelumab in patients with moderate-to-severe asthma. We also introduce the ongoing clinical trials in patients with asthma as well as future trials investigating the use of tezepelumab for other indications.
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