Integrative Analysis of the Immunological Significances of Guanylate Binding Protein Family Genes in Microsatellite Stability Colorectal Cancer

Microsatellite stability (MSS) colorectal cancer (CRC) has poor sensitivity to immunotherapy and its underlying mechanisms are still unclear. Guanylate binding proteins (GBPs) are a family of GTPase involving innate immune responses by providing defense against invading microbes and pathogens. However, the immunological significances of GBPs in MSS CRC remain unknown.