Magnetically Actuated Microrobot Equipped with Electron‐Extracting Nanohooks for Enhanced Photothermal Fungal Eradication

Abstract Fungal infections pose a formidable challenge in the healing of diabetic wounds due to complex inflammatory microenvironments, high resistance, and recurrence risks, particularly during fungal aggregation and germination stages. Inspired by controllable fishhooks, this work presents a magnetically actuated microrobot (Co@NCNH/NC) that leverages carbon nanohooks to enhance localized photothermal therapy. This microrobot features controllable navigation capabilities to pathogens in the magnetic field, enabling precise fungal capture and thermally promoted penetration even in high‐viscosity environments. With impact force and high conductivity, the microrobot's nanohooks induce disruption of cell envelopes and facilitate electron extraction from membranes, collectively compromising fungal integrity and enhancing fungal vulnerability. Thus, in situ, heat ablation further eradicates aggregated spores and causes irreversible damage to germinated fungi by aggravating cellular lysis, metabolic dysfunction, and destruction of actin cytoskeletons, inhibiting fungal self‐repair and growth. Moreover, Co@NCNH/NC with good biocompatibility exhibits catalase‐like activity that helps alleviate wound inflammation during therapy. This dual‐action approach accelerates critical wound healing processes including angiogenesis and epidermalization, ultimately improving healing outcomes in chronic diabetic wounds. By combining targeted fungal eradication with inflammation reduction and tissue regeneration, this adaptable microrobotic technology shows considerable promise for advancing therapeutic efficacy and prevention of recurrence in diabetic wound healing.