精神分裂症(面向对象编程)
心理学
认知
谷氨酸的
精神病
神经科学
人口
认知心理学
精神科
医学
谷氨酸受体
受体
环境卫生
内科学
作者
Clément Dondé,Joshua T. Kantrowitz,Alice Medalia,Alice M. Saperstein,Andrea Balla,Pejman Sehatpour,Antı́gona Martı́nez,Monica N. O’Connell,Daniel C. Javitt
标识
DOI:10.1016/j.neubiorev.2023.105098
摘要
Schizophrenia is a major mental disorder that affects approximately 1% of the population worldwide. Cognitive deficits are a key feature of the disorder and a primary cause of long-term disability. Over the past decades, significant literature has accumulated demonstrating impairments in early auditory perceptual processes in schizophrenia. In this review, we first describe early auditory dysfunction in schizophrenia from both a behavioral and neurophysiological perspective and examine their interrelationship with both higher order cognitive constructs and social cognitive processes. Then, we provide insights into underlying pathological processes, especially in relationship to glutamatergic and N-methyl-D-aspartate receptor (NMDAR) dysfunction models. Finally, we discuss the utility of early auditory measures as both treatment targets for precision intervention and as translational biomarkers for etiological investigation. Altogether, this review points out the crucial role of early auditory deficits in the pathophysiology of schizophrenia, in addition to major implications for early intervention and auditory-targeted approaches.
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