Chinese Guideline on Allergen Immunotherapy for Allergic Rhinitis: The 2022 Update

变应原免疫治疗 医学 指南 过敏原 免疫学 过敏 免疫疗法 疾病 重症监护医学 免疫系统 内科学 病理
作者
Chengshuo Wang,Yixiao Bao,Jianjun Chen,Xiaoyang Chen,Lei Cheng,Yin Shi Guo,Chuangli Hao,He Lai,Huabin Li,Jing Li,Changshan Liu,Yun Liu,Zheng Liu,Hongfei Lou,Wei Lv,Guangmin Nong,Qianhui Qiu,Xiumin Ren,Jie Shao,Yihong Shen
出处
期刊:Allergy, Asthma and Immunology Research [The Korean Academy of Asthma, Allergy and Clinical Immunology and The Korean Academy of Pediatric Allergy and Respiratory Disease]
卷期号:14 (6): 604-604 被引量:66
标识
DOI:10.4168/aair.2022.14.6.604
摘要

In the last few decades, there has been a progressive increase in the prevalence of allergic rhinitis (AR) in China, where it now affects approximately 250 million people. AR prevention and treatment include allergen avoidance, pharmacotherapy, allergen immunotherapy (AIT), and patient education, among which AIT is the only curative intervention. AIT targets the disease etiology and may potentially modify the immune system as well as induce allergen-specific immune tolerance in patients with AR. In 2017, a team of experts from the Chinese Society of Allergy (CSA) and the Chinese Allergic Rhinitis Collaborative Research Group (C2AR2G) produced the first English version of Chinese AIT guidelines for AR. Since then, there has been considerable progress in basic research of and clinical practice for AIT, especially regarding the role of follicular regulatory T (TFR) cells in the pathogenesis of AR and the use of allergen-specific immunoglobulin E (sIgE) in nasal secretions for the diagnosis of AR. Additionally, potential biomarkers, including TFR cells, sIgG4, and sIgE, have been used to monitor the incidence and progression of AR. Moreover, there has been a novel understanding of AIT during the coronavirus disease 2019 pandemic. Hence, there was an urgent need to update the AIT guideline for AR by a team of experts from CSA and C2AR2G. This document aims to serve as professional reference material on AIT for AR treatment in China, thus improving the development of AIT across the world.
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