氧化应激
抗氧化剂
厚壁菌
食品科学
微生态学
毛螺菌科
蜜柑
生物化学
化学
生物
植物
微生物学
16S核糖体RNA
基因
作者
Mengqi Fu,Xin Gao,Zuorui Xie,Chenlan Xia,Qing Gu,Ping Li
出处
期刊:Foods
[Multidisciplinary Digital Publishing Institute]
日期:2024-05-15
卷期号:13 (10): 1539-1539
被引量:2
标识
DOI:10.3390/foods13101539
摘要
Aging is characterized by the progressive degeneration of bodily tissues and decline in physiological functions, a process that may be exacerbated by imbalances in intestinal flora. Soluble dietary fiber (PSDF) from Citrus unshiu peel has demonstrated strong free radical scavenging ability to regulate intestinal flora in vitro. However, further evidence is required to ascertain the effectiveness of PSDF in vivo. In our study, 8-week-old mice were artificially aged through subcutaneous injections of a 200 mg/kg/d D-galactose solution for 42 days, followed by a 28-day dietary intervention with varying doses of PSDF, insoluble dietary fiber (PIDF), and vitamin C. After the intervention, we observed a significant mitigation of D-galactose-induced oxidative stress, as evident by weight normalization and reduced oxidative damage. 16S rRNA gene sequencing revealed that PSDF significantly altered the composition of intestinal flora, increasing Firmicutes and reducing Bacteroidota percentages, while also enriching colonic short-chain fatty acids (SCFAs). Spearman correlation analysis further identified a positive correlation between Firmicutes and isovaleric acid, and negative correlations between Muribaculaceae and acetic acid, and between Lachnospiraceae_NK4A136_group and caproic acid. These findings support the potential of Citrus PSDF to alleviate oxidative stress.
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