阻塞性睡眠呼吸暂停
医学
疾病
睡眠呼吸暂停
风险因素
阿尔茨海默病
睡眠(系统调用)
人口
内科学
生物信息学
神经科学
心理学
生物
计算机科学
环境卫生
操作系统
作者
Chih-Yun Kuo,Hung‐Ta Hsiao,Ing-Hsien Lo,Tomáš Nikolai
标识
DOI:10.3389/fnagi.2020.591737
摘要
Obstructive sleep apnea (OSA) and Alzheimer's disease (AD) are common in the elderly population. Obstructive sleep apnea that may cause significant changes in the cerebrospinal fluid β-amyloid and T-tau and/or P-tau protein levels is often identified as a risk factor for development of AD. Although the underlying mechanisms of AD are still not fully understood, a hypothesis associating OSA with AD has been already proposed. In this systematic mini-review, we first discuss the recent findings supporting the association of OSA with an increased risk of AD and then provide evidence suggesting the positive effect of OSA treatment on a reduced risk of AD.
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