生物
适应(眼睛)
肠道菌群
共生
表型
谱系(遗传)
寄主(生物学)
实验进化
宿主适应
进化生物学
细菌
遗传学
基因组
基因
免疫学
神经科学
作者
Hugo C. Barreto,Ana Sousa,Isabel Gordo
出处
期刊:Current Biology
[Elsevier]
日期:2020-03-01
卷期号:30 (6): 1102-1109.e5
被引量:39
标识
DOI:10.1016/j.cub.2020.01.037
摘要
Aging is a complex process, with many associated time-dependent phenotypes. The gut microbiota have long been postulated as an important factor in shaping healthy aging [1, 2]. During aging, changes in the microbiota composition occur, with taxa that are rare in adults becoming dominant in the elderly [3, 4]. Increased inflammation associated with aging is also known to modulate and be modulated by the microbiota [5]. Ecological interactions are known to affect the evolution of bacteria both in vitro [6] and in vivo [7], but the extent to which these and the host age-dependent inflammatory environment can alter the pattern of evolutionary change of a gut commensal lineage is still unknown [8]. Here, we provide the first genomic analysis of such evolution in cohorts of old mice, under controlled host genetics and lifestyle conditions. We find that Escherichia coli evolution when colonizing the gut of old mice significantly differs from its evolution in young mice. Evolution toward metabolic adaptation is slower in old than young mice, and mutational targets concerning stress-related functions were found specifically in the inflamed gut of old mice. Taking the genetic basis of E. coli short-term evolution as a reflection of the environment it experiences, the sequencing data indicate that aging imposes a more stressful environment to this important colonizer of the mammalian gut.
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