Carbonylations of Alkenes in the Total Synthesis of Natural Compounds

The goal of this review is to highlight the applications of carbonylation reactions of alkenes in the total synthesis of natural compounds. These highly atom-economic reactions, which are known for their industrial applications, constitute attractive synthetic methodologies for the selective construction of carbonyl compounds. We aimed at the selection of recent methodologically attractive syntheses where carbonylations were applied as key steps. In addition, a few examples of the related carbonylation of allenes are shown. 1 Introduction 2 Hydroformylation 3 Hydroaminomethylation and Related Tandem Hydroformylation Reactions 4 Reppe Carbonylation 5 Allylic Carbonylation 6 Oxidative Carbonylation 7 Pauson–Khand Reaction 8 Summary and Outlook