Senescent immune cells release grancalcin to promote skeletal aging

(Cell Metabolism 33, 1957–1973.e1–e6; October 5, 2021) In the originally published version of this article, an incorrect micro-CT image was mistakenly used while constructing Figure 3A, and double-labeling images were mistakenly used during editing in Figure 7N. These errors have now been corrected online. The errors do not affect the conclusions of the paper. The authors apologize for any confusion that may have resulted.Figure 3A. Mice with deletion of Gca in neutrophils and macrophages show improved skeletal aging (original)View Large Image Figure ViewerDownload Hi-res image Download (PPT)Figure 7N. GCA-neutralizing antibody treatment improves skeletal health (corrected)View Large Image Figure ViewerDownload Hi-res image Download (PPT)Figure 7N. GCA-neutralizing antibody treatment improves skeletal health (original)View Large Image Figure ViewerDownload Hi-res image Download (PPT) Senescent immune cells release grancalcin to promote skeletal agingLi et al.Cell MetabolismSeptember 9, 2021In BriefAging is marked by reduced osteogenesis and increased adipogenesis of bone marrow stromal cells, leading to bone fragility. Here, Li et al. show that senescent immune cells contribute to this process by accumulating in the bone marrow, where they secrete the protein grancalcin, which suppresses bone turnover and promotes marrow fat accumulation. Full-Text PDF